Optically active phosphine oxides. 2. Novel approach to enantiomeric dialkylphenylphosphine oxides

KM Pietrusiewicz, M Zablocka…

文献索引：Pietrusiewicz, K. Michal; Zablocka, Maria; Monkiewicz, Jaroslaw Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1522 - 1526

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被引用次数: 61

摘要

New routes to optically active tertiary phosphine oxides of known configuration and of virtually 100% enantiomeric purity have been developed. Alkylation of (-)-(Sp)-ethyl ((menthoxycarbonyl) methyl) phenylphosp~ ne oxide (2) by treatment with equimolar amounts of sodium hydride and alkyl halide in tetrahydrofuran followed by decarbalkoxylation with LiCl in wet MezSO affords (-)-(Rp)-alkylethylphenylphosphine ...