Synthesis and biological activity of 2-aminoalkyl (aryl)-3-phenyl-5-nitroindoles

AI Grinev, ES Krichevskii, OB Romanova…

文献索引：Grinev, A. I.; Krichevskii, E. S.; Romanova, O. B.; Filipenko, T. Ya.; Polezhaeva, A. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 635 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1066 - 1072

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摘要

2-Methyl-3-phenyl-5-nitroindole (I), previously obtained by the Fischer reaction in a low yield [2, 3], served as the starting material. However, by changing the conditions of the indolization reaction of p-nitrophenylhydrazone of benzyl methyl ketone, we were able to increase the yield of compound I to 70%. l-Alkyl (aralkyl)-2-methyl-3-phenyl-5- nitroindoles(IIa-c) were synthesized in an 80-97% yield by alkylation of I by dimethyl and ...