A large series of 4-arylcoumarins was synthesized by Suzuki-Miyaura cross-coupling reaction and evaluated for antiprotozoal activity against Plasmodium falciparum and Leishmania donovani. Several compounds were found to strongly inhibit the proliferation of human cell line and/or parasites. The 4-(3, 4-dimethoxyphenyl)-6, 7-dimethoxycoumarin exhibit a potent activity on L. donovani amastigotes with a selectivity index (SI= 265) twice ...
