Pharmaceutical research

Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl ester prodrugs of carboxylic acid agents

J Iley, R Moreira, T Calheiros, E Mendes

文献索引：Iley, Jim; Moreira, Rui; Calheiros, Teresa; Mendes, Eduarda Pharmaceutical Research, 1997 , vol. 14, # 11 p. 1634 - 1639

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被引用次数: 28

摘要

Abstract Purpose. Novel tertiary amidomethyl esters were synthesized and evaluated as potential prodrugs of carboxylic acid agents. Methods. The hydrolyses of the title compounds in buffer solutions and in plasma were studied by UV spectroscopy and HPLC. Results. Amidomethyl esters were hydrolyzed by acid-catalyzed, base-catalyzed and pH- independent pathways. Both the acid-catalyzed, k _ H^+, and pH-independent processes, ...