SiO 2 nanoparticles as platform for delivery of nucleoside triphosphate analogues into cells

SV Vasilyeva, VN Silnikov, NV Shatskaya…

文献索引：Vasilyeva, Svetlana V.; Silnikov, Vladimir N.; Shatskaya, Natalia V.; Levina, Asya S.; Repkova, Marina N.; Zarytova, Valentina F. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 3 p. 703 - 711

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被引用次数: 9

摘要

A system for delivery of analogues of 2′-deoxyribonucleoside triphosphate (dNTP) based on SiO2 nanoparticles was proposed. A simple and versatile method was developed for the preparation of SiO2–dNTP conjugates using the 'click'-reaction between premodified nanoparticles containing the azido groups and dNTP containing the alkyne-modified γ- phosphate group. The substrate properties of SiO2–dNTP were tested using Klenow ...