Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase

P Chand, PL Kotian, PE Morris, S Bantia…

文献索引：Chand, Pooran; Kotian, Pravin L.; Morris, Philip E.; Bantia, Shanta; Walsh, David A.; Babu, Yarlagadda S. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2665 - 2678

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被引用次数: 43

摘要

Based upon the activity and X-ray crystallographic studies of tri-substituted benzene derivatives containing carboxylic acid, acetamido and guanidine groups, we investigated the effect of the fourth substituent to fulfill the fourth pocket of neuraminidase enzyme. The groups selected as fourth substituents were hydroxymethyl, hydroxyethyl, oxime and amino. These tetra-substituted benzene derivatives were synthesized and evaluated for ...