Toward an artificial oxidative DNA photolyase

M Pauvert, P Laine, M Jonas…

文献索引：Pauvert, Mickael; Laine, Patrick; Jonas, Marco; Wiest, Olaf Journal of Organic Chemistry, 2004 , vol. 69, # 2 p. 543 - 548

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被引用次数: 32

摘要

The design, synthesis, structure, and binding affinity of two dioptic receptors for the selective molecular recognition of the cis, syn cyclobutane pyrimidine dimer are reported. The design is based on two 2, 6-di (acetamino) pyridine recognition units that are covalently linked via triple bonds to an anthraquinone functional spacer unit. The convergent synthesis uses a modified Sonogashira reaction involving a zinc transmetalation as the key step. The ...