Bioorganic & medicinal chemistry letters

3, 3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

S Hosoda, Y Hashimoto

文献索引：Hosoda, Shinnosuke; Hashimoto, Yuichi Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 19 p. 5414 - 5418

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被引用次数: 11

摘要

We designed and synthesized novel type 1 5α-reductase inhibitors by using 3, 3- diphenylpentane skeleton as a substitute for the usual steroid skeleton. 4-(3-(4-(N- Methylacetamido) phenyl) pentan-3-yl) phenyl dibenzylcarbamate (11k) is a competitive 5α- reductase inhibitor with the IC50 value of 0.84 μM.