[(6, 7-Dichlorobenzo [b] thien-5-yl) oxy] acetic acids and 1, 1-dioxides. 1. A structurally novel class of diuretics with hypotensive activity

…, SR Caldwell, JA Profitt, JJ Tegeler…

文献索引：Ong, Helen H.; Caldwell, Steven R.; Profitt, James A.; Tegeler, John J.; Agnew, Marc N.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 12 p. 2295 - 2303

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被引用次数: 3

摘要

73-90 91-102 iated derivative of 24 reacted readily with both DMF and paraformaldehyde to give 36 and 38, respectively. Further elaboration of the phenolic hydroxyl function into an (ary1oxy) acetic acid side chain is illustrated in Scheme 111. Phenols 39-56 were reacted with a slight excess of ethyl bromoacetateg in the presence of K2C03 and DMF to give (ary1oxy) acetates 57-72 in excellent yields (method I), and the esters were readily ...