Cytotoxicities, cell cycle and caspase evaluations of 1, 6-diaryl-3 (Z)-hexen-1, 5-diynes, 2-(6-aryl-3 (Z)-hexen-1, 5-diynyl) anilines and their derivatives

CF Lin, YH Lo, MC Hsieh, YH Chen, JJ Wang…

文献索引：Lin, Chi-Fong; Lo, Yu-Hsiang; Hsieh, Ming-Chu; Chen, Yi-Hua; Wang, Jeh-Jeng; Wu, Ming-Jung Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 10 p. 3565 - 3575

全文：HTML全文

被引用次数: 30

摘要

Compounds 3, 6–7, 9–10, 15–17, and 20–21 showed growth inhibition effects on a full panel of 60 human cancer cell lines, and most of the average IC50 values of the indicated analogues were from< 0.01 to 96.6 μM, in which analogues 16 and 17 revealed the highest cytotoxic activity with the cancer cell lines at 10− 7M concentration range. During the cell cycle analysis, a moderate to high apoptotic progress induction was shown by 3, 9, 16–17, ...