We describe here the synthesis and biological activity of new 8-azaadenines bearing both a phenyl group on C (2) and a 9-benzyl group substituted in the ortho position with a Cl or a F atom or a CF3 group, to verify the synergistic effect of a combination of these substitution patterns on binding with the A1 adenosine receptors. In position N6 aliphatic and cycloaliphatic substituents were chosen which had been shown to bind well with the A1 ...
