2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents

…, M Falahati, E Lotfali, S Rajabalian, SA Ebrahimi…

文献索引：Emami, Saeed; Foroumadi, Alireza; Falahati, Mehraban; Lotfali, Ensieh; Rajabalian, Saeed; Ebrahimi, Soltan-Ahmed; Farahyar, Shirin; Shafiee, Abbas Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 141 - 146

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被引用次数: 73

摘要

2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25–32μg/mL comparable to reference drug fluconazole. The most active compounds ...