European Journal of Medicinal Chemistry

Synthesis, anticonvulsant activity and 3D-QSAR study of some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole

ND Amnerkar, KP Bhusari

文献索引：Amnerkar, Nikhil D.; Bhusari, Kishore P. European Journal of Medicinal Chemistry, 2010 , vol. 45, # 1 p. 149 - 159

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被引用次数: 109

摘要

A series of 6-substituted-[3-substituted-prop-2-eneamido] benzothiazole 9–32 and 6- substituted-2-[(1-acetyl-5-substituted)-2-pyrazolin-3-yl] aminobenzothiazole 33–56 were synthesized using appropriate synthetic route and evaluated experimentally against maximal electroshock test. Selected compounds were evaluated for neurotoxicity, hepatotoxicity and behavioral study. The most active compound, 6-methyl-2-[(1-acetyl-5-(4 ...