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Hydrolysis of 2′-deoxypurine nucleosides. The effect of substitution at the C-8 position

A Laayoun, JL Décout, J Lhomme

文献索引:Laayoun, Ali; Decout, Jean-Luc; Lhomme, Jean Tetrahedron Letters, 1994 , vol. 35, # 28 p. 4989 - 4990

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被引用次数: 30

摘要

Abstract The hydrolytic stability of 2′-deoxypurine nucleosides is decreased by introduction of electron-withdrawing substituents at the C-8 position in the series of compounds 2–8, 10– 14. The sulfone group causes a 2.9× 10 4 rate acceleration for glycosidic bond cleavage in compound 14.