Biologically oriented organic sulfur chemistry. 8. Structure-activity relations of penicillamine analogs and derivatives

…, ST Ticaric, PL Kelly, P Merryman, IA Jaffe

文献索引：Sweetman; Vestling; Ticaric; Kelly; Field; Merryman; Jaffe Journal of medicinal chemistry, 1971 , vol. 14, # 9 p. 868 - 872

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被引用次数: 1

摘要

D-Penicillamine (1) is of interest for the treatment of rheumatoid arthritis, but it, causes many side effects. Evaluation of substances structurally related to 1 was made for effectiveness in reducing the tensile strength of rat skin in civo, a parameter of 1 significant to collagen biochemistry, if not to rheumatoid arthrit, is. The moieties SH," 2, and COtH all appeared to be necessary for reduction of tensile strength, for activity was lacking whenever any one of ...