Synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells

L Espinoza Catalan, A Madrid Villegas…

文献索引：Catalan, Luis Espinoza; Villegas, Alejandro Madrid; Liber, Lautaro Taborga; Garcia, Joan Villena; Fritis, Mauricio Cuellar; Altamirano, Hector Carrasco Journal of the Chilean Chemical Society, 2010 , vol. 55, # 2 p. 219 - 222

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被引用次数: 5

摘要

ABSTRACT Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives,(2E')-3-(3', 4'- ...