Tetrahedron letters

Synthesis of functionalized nitrogen heterocycles from β-and γ-amino acids by radical decarboxylation

A Boto, R Hernández, Y de León, JR Murguı́a…

文献索引：Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail Tetrahedron Letters, 2004 , vol. 45, # 37 p. 6841 - 6845

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被引用次数: 15

摘要

The radical decarboxylation of β-and γ-amino acids on treatment with PhI (OAc) 2–I2 is a mild and efficient methodology to synthesize halogenated or oxygenated nitrogen heterocycles. The reaction was applied to the synthesis of bioactive products, such as opioid analogues, iminosugars and new antifungic agents.