Tetrahedron Letters

InCl 3 catalyzed carbene insertion into O–H bonds: efficient synthesis of ethers

PR Krishna, YL Prapurna, M Alivelu

文献索引：Radha Krishna, Palakodety; Prapurna, Y. Lakshmi; Alivelu, Munagala Tetrahedron Letters, 2011 , vol. 52, # 27 p. 3460 - 3462

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被引用次数: 8

摘要

Abstract An efficient InCl 3 mediated insertion of the carbene fragment (: CHCO 2 Et), generated in situ from ethyl diazoacetate into O–H bond of a series of saturated and unsaturated alcohols under mild conditions has been developed to afford the corresponding ethers as exclusive products in good to high yields (70–95%) and in shorter reaction times. In the case of unsaturated alcohols, the reaction proceeded with unprecedented selectivity ...