Rhodium chemzymes: Michaelis-Menten kinetics in dirhodium (II) carboxylate-catalyzed carbenoid reactions

MC Pirrung, H Liu, AT Morehead

文献索引：Pirrung, Michael C.; Liu, Hao; Morehead Jr., Andrew T. Journal of the American Chemical Society, 2002 , vol. 124, # 6 p. 1014 - 1023

全文：HTML全文

被引用次数: 100

摘要

Rhodium carboxylate-mediated reactions of diazoketones involving cyclopropanation, CH insertion, and aromatic CC double bond addition/electrocyclic ring opening obey saturation (Michaelis-Menten) kinetics. Axial ligands for rhodium, including aromatic hydrocarbons and Lewis bases such as nitriles, ethers, and ketones, inhibit these reactions by a mixed kinetic inhibition mechanism, meaning that they can bind both to the free catalyst and to the ...