Chiral N-benzyl-N-methyl-1-(naphthalen-1-yl) ethanamines and their in vitro antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and …
THK Thvedt, K Kaasa, E Sundby, C Charnock…
文献索引：Krane Thvedt, Thor H.; Kaasa, Kristin; Sundby, Eirik; Charnock, Colin; Hoff, Bard Helge European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 482 - 496
Abstract In the search for new antifungal compounds and to explore structure activity relationships, a series of 24 chiral benzyl amine type antifungals was synthesised and characterised. In vitro testing against the human pathogen Cryptococcus neoformans revealed that several derivatives had MIC 50 values similar to that of the commercial drug Butenafine. All of these contained a bulky group in the para position of the benzyl ...
