N-benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing properties

DR Buckle, DJ Outred, H Smith…

文献索引：Buckle, Derek R.; Outred, D. James; Smith, Harry; Spicer, Barbara A. Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1452 - 1457

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被引用次数: 16

摘要

In a small range finding study a number of N-benzylpiperazino derivatives of 3-nitro-4- hydroxycoumarin have been shown to combine potent HI-antihistamine activity with that of mast cell stabilization as demonstrated by their activity as antagonists of histamine on guinea pig ileum and by their inhibition of the release of histamine in rat passive peritoneal anaphylaxis (PPA). The most potent compound, 1-[2-hydroxy-3-[(4-hydroxy-3- ...