The Journal of Organic Chemistry

The Alkylation of 6-(Trifluoromethyl)-1, 2, 4-benzothiadiazine-7-sulfonamide 1, 1-Dioxide and Related Compounds. A New Reaction of ortho Esters with …

HL YALE, JT SHEEHAN

文献索引：Yale,H.L.; Sheehan,J.T. Journal of Organic Chemistry, 1961 , vol. 26, p. 4315 - 4325

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被引用次数: 13

摘要

A new reaction of ortho esters with 1, 2, 4benzothiadiazine 1, l-dioxides and pyridothiadiazine 1, l-dioxides is described. These react at 150'to give a mixture of the 2-and 4alkylated derivatives, thus confirming for the first time the previously postulated existence of mobile hydrogen atom tautomerism and, consequently, an unsymmetrical triad system in this class of heterocyclic compounds. The reaction is generally applicable but will proceed to ...