A Simple and Efficient New Approach to the Total Synthesis of (±)-4-Amino-3-(4-Chlorophenyl)-Butyric Acid (BACLOFEN)

F Coelho, MBM de Azevedo, R Boschiero…

文献索引：Coelho, Fernando; De Azevedo, Mariangela B. M.; Boschiero, Roberta; Resende, Patricia Synthetic Communications, 1997 , vol. 27, # 14 p. 2455 - 2465

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被引用次数: 12

摘要

Abstract Based on the utilization of a [2+ 2] cycloaddition reaction between dichloroketene and an appropriated olefin as a key step, we describe a new and simple four step approach to the total synthesis of (±)-4-amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN), a selective GABAB agonist used as antispastic agent