Quinolone antimicrobial agents. 2. Methylenedioxy positional isomers of oxolinic acid

LA Mitscher, DL Flynn, HE Gracey…

文献索引：Mitscher,L.A. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 1354 - 1357

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被引用次数: 14

摘要

The synthesis and antimicrobial activity of the methylenedioxy positional isomers, l-ethyl-1, 4- dihydro-5, 6-methylenedioxy-4-oxo-3-quinolinecarboxylic acid (9) and l-ethyl-l, 4-dihydro-7, 8-methylenedioxy-4-oxo-3-quino-linecarboxylic acid (17), of oxolinic acid (18) have been accomplished. Isomer 9 was prepared by the reaction of N-ethyl-6, 7-methylenedioxyisatoic anhydride with sodioethyl formylacetate [LA Mitscher, HE Gracey, GW Clark 111, and T. ...