Tetrahedron Letters

An efficient base-mediated intramolecular condensation of 2-(disubstituted amino)-benzonitriles to 3-aminoindoles

CM Seong, CM Park, J Choi, NS Park

文献索引：Seong, Churl Min; Park, Chul Min; Choi, Jinil; Park, No Sang Tetrahedron Letters, 2009 , vol. 50, # 9 p. 1029 - 1031

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被引用次数: 12

摘要

3-Aminoindoles are unique intermediates in the substituted indole synthesis, and have been produced by hydrolysis of the corresponding isocyanates, 5 by reduction of the salts of isonitrosoindoles obtained from indoles, 6 or by the Fischer cyclization of the phenylhydrazines of ω-(N-acylamino)acetophenones. 7 The 3-aminoindole formation by cyclization under basic conditions also remains challenging. 8 In connection with these studies, we envisioned that the ...