KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue

H Yamakoshi, N Kanoh, C Kudo, A Sato…

文献索引：Yamakoshi, Hiroyuki; Kanoh, Naoki; Kudo, Chieko; Sato, Atsuko; Ueda, Kazunori; Muroi, Makoto; Kon, Shunsuke; Satake, Masanobu; Ohori, Hisatsugu; Ishioka, Chikashi; Oshima, Yoshiteru; Osada, Hiroyuki; Chiba, Natsuko; Shibata, Hiroyuki; Iwabuchi, Yoshiharu ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 6 p. 273 - 276

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被引用次数: 16

摘要

Bis (arylmethylidene) acetone derivatives are an important class of curcumin analogues that exhibit various biological and pharmacological activities. We herein report that GO-Y086, a biotinylated bis (arylmethylidene) acetone, inhibits cancer cell growth. We also show that GO- Y086 specifically interacts with the nuclear protein KSRP/FUBP2 by covalent modification. GO-Y086 markedly suppresses the expression of the c-Myc protein, which plays an ...