Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1, 3-naphth-oxazines

S Ihmaid, J Al-Rawi, C Bradley, MJ Angove…

文献索引：Ihmaid, Saleh; Al-Rawi, Jasim; Bradley, Christopher; Angove, Michael J.; Robertson, Murray N.; Clark, Rachel L. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 13 p. 3983 - 3994

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被引用次数: 11

摘要

Abstract A number of new angular 2-morpholino-(substituted)-naphth-1, 3-oxazines (compound 10b), linear 2-morpholino-(substituted)-naphth-1, 3-oxazines (compounds 13b– c), linear 6, 7 and 9-O-substituted-2-morpholino-(substituted)-naphth-1, 3-oxazines (compounds 17–22, 24, and 25) and angular compounds 14–16 and 23 were synthesised. The O-substituent was pyridin-2yl-methyl (15, 18, and 21) pyridin-3yl-methyl (16, 19, and ...