Journal of medicinal chemistry

Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy

JD Conley, H Kohn

文献索引：Conley, Judith D.; Kohn, Harold Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 567 - 574

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被引用次数: 58

摘要

Structural analogues of the potent known anticonvulsant agent N-acetyl-DL-alanine N- benzylamide (la) have been prepared (16 examples). The pharmacological activities of these products were evaluated in the maximal electroshock seizure (MES), the subcutaneous pentylenetetrazole seizure threshold (sc Met), and the rotorod (Tox) tests. The median effective doses (ED50) and the median toxic doses (TD50) for the most active ...