Tetrahedron: Asymmetry

Production of ring-substituted D-phenylglycines by microbial or enzymatic hydrolysis/deracemisation of the corresponding DL-hydantoins

MJ Garcia, R Azerad

文献索引：Garcia, Maria J.; Azerad, Robert Tetrahedron Asymmetry, 1997 , vol. 8, # 1 p. 85 - 92

全文：HTML全文

被引用次数: 46

摘要

A series of 17 ring-mono and-disubstituted D-phenylglycine derivatives was prepared in high enantiomeric purity by enzymatic hydrolysis and deracemisation of the corresponding DL-hydantoins, using D-hydantoinase activities of microorganisms or purified enzymes, followed by diazotation of the resulting N-carbamyl D-amino acids. No significant L- hydantoinase activity was found to produce the corresponding L-enantiomers.