Nucleosides & nucleotides

Synthesis and biochemical activity of hydrophilic carborane-containing pyrimidine nucleosides as potential agents for DNA incorporation and BNCT

FG Rong, AH Soloway, S Ikeda…

文献索引：Rong, Feng-Guang; Soloway, Albert H.; Ikeda, Seiichiro; Ives, David H. Nucleosides and Nucleotides, 1997 , vol. 16, # 4 p. 379 - 401

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被引用次数: 21

摘要

Abstract A novel type of hydrophilic 5-tethered carborane-containing 2′-deoxyuridine derivative, SUB-7-DIOL, has been developed. This compound is a potential agent for DNA incorporation and BNCT, because it showed satisfactory aqueous solubility and demonstrated an excellent rate of phosphorylation by human thymidine kinase. This study also demonstrated the importance of tethering a flexible hydrocarbon chain between the ...