Centre de Recherche Merrell International, 67084 Strasbourg CEder, France. Received July 1, 1980 a-Ethynyl-and a-vinylomithine were designed and synthesized as potential enzymeactivated inhibitors of" ah'an ornithine decarboxylase. These two new inhibitors produce both immediate and time-dependent inhibition of rat liver ornithine decarboxylase in vitro. The inhibitions exhibit saturation kinetics. The apparent dissociation constanta (Kr) ...
