Tetrahedron letters

2-Chloroquinazoline. Synthesis and reactivity of a versatile heterocyclic building block

ST Henriksen, US Sørensen

文献索引：Henriksen, Signe Teuber; Sorensen, Ulrik Svane Tetrahedron Letters, 2006 , vol. 47, # 47 p. 8251 - 8254

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被引用次数: 13

摘要

Starting from 2, 4-dichloroquinazoline, various methods for the selective removal of the 4- chloro substituent were tested, including catalytic hydrogenation, metal–halogen exchange, metal hydride reduction and reduction with tributyltin hydride—the latter both in a radical and in a Stille-type reaction. Amongst these, the most efficient method was found to be the Stille- type coupling. Furthermore, we have studied the reactivity of 2-chloroquinazoline and ...