New synthesis of isoquinoline and 3, 4-dihydroisoquinoline derivatives

…, K Hashimoto, O Morikawa, H Konishi

文献索引：Kobayashi, Kazuhiro; Shiokawa, Taiyo; Omote, Hiroki; Hashimoto, Kenichi; Morikawa, Osamu; Konishi, Hisatoshi Bulletin of the Chemical Society of Japan, 2006 , vol. 79, # 7 p. 1126 - 1132

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被引用次数: 11

摘要

A simple and efficient synthesis of isoquinoline and 3, 4-dihydroisoquinoline derivatives is described. 1-Alkyl (or aryl) isoquinoline and 1-isoquinolinamine derivatives were obtained by intramolecular cyclization of 2-(2-methoxyethenyl) benzonitriles initiated by the addition of alkyl (or aryl) lithiums and lithium dialkylamides to the nitrile carbons, respectively. Synthesis of 4-aryl-3, 4-dihydroisoquinolines was achieved by reactions of 2-(1- ...