Synthesis and inhibitory evaluation of cyclohexen-2-yl-and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells

…, Y Ou, S Chen, X Lu, H Cheng, X Jia, D Wang…

文献索引：Liu, Xin; Ou, Yingyong; Chen, Shaopeng; Lu, Xin; Cheng, Hao; Jia, Xian; Wang, Decai; Zhou, Guo-Chun European Journal of Medicinal Chemistry, 2010 , vol. 45, # 6 p. 2147 - 2153

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被引用次数: 6

摘要

Alkylation of phenols with 1, 3-cyclohexadiene (1) has been conducted and a series of cyclohexen-2-yl-and cyclohexyl-substituted phenols and quinones were screened against the proliferation of HUVEC and cancer cells. Phenol type as well as the size and occupied position of the substitute are important for the alkylating reaction and the inhibitory activity and selectivity of a compound. 2, 5-Di (cyclohexen-2-yl) benzene-1, 4-diol (25) bearing ...