New analogues of AHMA as potential antitumor agents: synthesis and biological activity

…, V Bacherikov, TC Chou, CH Chen, H Dong…

文献索引：Chang, Jang-Yang; Lin, Chyun-Feng; Pan, Wen-Yu; Bacherikov, Valeriy; Chou, Ting-Chao; Chen, Ching-Huang; Dong, Huajin; Cheng, Shu-Yun; Tasi, Tsong-Jen; Lin, Yi-Wen; Chen, Kuo-Tung; Chen, Li-Tzong; Su, Tsann-Long Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4959 - 4969

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被引用次数: 32

摘要

A series of new analogues of 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA, 1) and AHMA-ethylcarbamate (2) were synthesized by introducing an O-alkylcarboxylic acid esters to the CH2OH function, displacing the CH2OH function with a dimethylaminocarboxamido group or with a methyl function introduced at the meta-, para-or ortho-position to the NH2 group to form 5-(9-acridinylamino)-m-toluidines (AMTs), 5-(9-acridinylamino)-p-toluidines ...