Antihypertensive thiadiazoles. 1. Synthesis of some 2-aryl-5-hydrazino-1, 3, 4-thiadiazoles with vasodilator activity

S Turner, M Myers, B Gadie, AJ Nelson…

文献索引：Turner, Stephen; Myers, Malcolm; Gadie, Brian; Nelson, Anthony J.; Pape, Robin; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 902 - 906

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被引用次数: 93

摘要

Some 2-aryl-5-hydrazino-l, 3, 4-thiadiazoles have been synthesized and screened for antihypertensive activity. In general, compounds with a 2-substituted phenyl ring had higher activity than their 3-or 4-substituted counterparts or those containing heteroaryl groups. The 2-methylphenyl and 2-ethylphenyl derivatives 7 and 18 were the most potent members of the series. Preliminary studies indicated that the hypotensive action of these compounds ...