2-[(4-phenylpiperazin-1-yl) methyl] imidazo (di) azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl) piperazin-1-ylmethyl] imidazo [1 …

C Enguehard-Gueiffier, H Hübner…

文献索引：Enguehard-Gueiffier, Cecile; Huebner, Harald; El Hakmaoui, Ahmed; Allouchi, Hassan; Gmeiner, Peter; Argiolas, Antonio; Melis, Maria Rosaria; Gueiffier, Alain Journal of Medicinal Chemistry, 2006 , vol. 49, # 13 p. 3938 - 3947

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被引用次数: 65

摘要

A series of novel 2-[(4-phenylpiperazin-1-yl) methyl] imidazoazines and aza-analogues were prepared and screened at selected dopamine, serotonin, and adrenergic receptor subtypes. 2-Substituted imidazopyridines and pyridazines presented high affinities and selectivities for D4 dopamine receptors. Whereas functional experiments indicated neutral antagonists or weak partial agonist effects for most of the target compounds, the 2- ...