Bioavailability and anticonvulsant activity of 2??cyanoguanidinophenytoin, a structural analogue of phenytoin
…, B Masereel, B Gallez, M Geurts…
文献索引：Lambert, Didier M.; Masereel, Bernard; Gallez, Bernard; Geurts, Muriel; Scriba, Gerhard K. E. Journal of Pharmaceutical Sciences, 1996 , vol. 85, # 10 p. 1077 - 1081
Abstract Phenytoin is extensively used in Europe and the United States for the treatment of generalized tonic clonic seizures (grand mal). However, the efficacy is lowered by the erratic bioavailability after oral administration. The current study was conducted in order to investigate the physicochemical properties, the bioavailability, and the anticonvulsant activity of cyanoguanidinophenytoin (CNG-DPH), a structural analogue of phenytoin, ...
