Assembly of Substituted Phenothiazines by a Sequentially Controlled CuI/L??Proline??Catalyzed Cascade C S and C N Bond Formation

D Ma, Q Geng, H Zhang, Y Jiang

文献索引：Dawei, Ma.; Geng, Qian; Zhang, Hui; Jiang, Yongwen Angewandte Chemie - International Edition, 2010 , vol. 49, # 7 p. 1291 - 1294

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被引用次数: 80

摘要

The phenothiazine structural motif has been successfully employed in the design of a variety of pharmaceuticals. Successful examples include promazine drugs (1a–c), which are clinically used for psychotropic medication;[1] quaternized trifluoropromazine derivative 2 that has antitubercular activity;[2] cholinesterase inhibitor 3;[3] histamine H1 antagonist 4;[4] and MDR (multiple drug resistance) reverting agent 5.[5] Substituted phenothiazines have ...