Discovery and characterization of synthetic 4′-hydroxyflavones—new CK2 inhibitors from flavone family

…, AO Prykhod'ko, OP Kukharenko, SM Yarmoluk

文献索引：Golub, Andriy G.; Bdzhola, Volodymyr G.; Ostrynska, Olga V.; Kyshenia, Iaroslav V.; Sapelkin, Vladislav M.; Prykhod'Ko, Andriy O.; Kukharenko, Olexander P.; Yarmoluk, Sergiy M. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6681 - 6689

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被引用次数: 12

摘要

Abstract Human protein kinase CK2 is one of the most intriguing enzymes, which functional role still remains unclear despite of decades of studying. At present there is abundant evidence pointing to the fact that inhibitors of CK2 could be used as pharmaceutical agents to treat cancer, viral infections and inflammatory diseases. Here we report novel synthetic flavone inhibitors, 4′-hydroxyflavones, possessing high activity towards CK2. These ...