Synthesis of N α-(1-Phenyl-2-mercaptoethyl) Amino Acids, New Building Blocks for Ligation and Cyclization at Non-Cysteine Sites: Scope and Limitations in Peptide …

S Tchertchian, O Hartley, P Botti

文献索引：Tchertchian, Sylvie; Hartley, Oliver; Botti, Paolo Journal of Organic Chemistry, 2004 , vol. 69, # 26 p. 9208 - 9214

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被引用次数: 25

摘要

A new and convenient method for the synthesis and incorporation of N α-(1-phenyl-2- mercaptoethyl)-derivatized amino acids applicable to chemical ligation at non-cysteine sites is presented. N α-Auxiliary derivatives of glycine and alanine were easily prepared using reductive amination approaches. Several strategies for the incorporation of these derivatives into peptide chains were investigated: coupling without protection, with acid-labile ...