Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate

J Regan, S Breitfelder, P Cirillo, T Gilmore…

文献索引：Journal of Medicinal Chemistry, , vol. 45, # 14 p. 2994 - 3008

全文：HTML全文

被引用次数: 317

摘要

... Departments of Medicinal Chemistry, Biology, and Pharmacology, Boehringer Ingelheim Pharmaceuticals, Research and ... applications on imidazole-based compounds, 25-27 several journal papers have ... Following the chemistry described in Scheme 1, pyrazole formation and ...