Tetrahedron letters

Synthesis of a novel hexadentate chelating agent based on8-hydroxyquinoline

WD Shrader, J Celebuski, SJ Kline, D Johnson

文献索引：Shrader, William D.; Celebuski, Joseph; Kline, Steven J.; Johnson, David Tetrahedron Letters, 1988 , vol. 29, # 12 p. 1351 - 1354

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被引用次数: 22

摘要

Abstract A new hexadentate chelator was synthesized by the functionalization of 8- hydroxyquinoline to its 2-carboxy-N-hydroxysuccinimidyl ester and subsequent condensation with tris (2-aminoethyl) amine to givetris-N-(2-aminoethyl-[8-hydroxyquinoline- 2-carboxamido]) amine. This molecule is a siderophore analog with a non-naturally occurring binding unit comprising a combination of both oxygen and nitrogen donor atoms.