Investigation of the configurational stabilities of chiral isocyanoacetates in multicomponent reactions

DW Carney, JV Truong, JK Sello

文献索引：Carney, Daniel W.; Truong, Jonathan V.; Sello, Jason K. Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10279 - 10285

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被引用次数: 15

摘要

Isocyanoacetates are uniquely reactive compounds characterized by an ambivalent isocyano functional group and an enolizable α-carbon. It is widely believed that chiral α- substituted isocyanoacetates are configurationally unstable in some synthetically useful isocyanide-based multicomponent reactions. Herein, we demonstrate that chiral isocyanoacetates can be used with minimal to negligible epimerization in a variety of ...