Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

…, M Bertinaria, B Rolando, R Fruttero, CD Lucas…

文献索引：Montanaro, Gabriele; Bertinaria, Massimo; Rolando, Barbara; Fruttero, Roberta; Lucas, Christopher D.; Dorward, David A.; Rossi, Adriano G.; Megson, Ian L.; Gasco, Alberto Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 2107 - 2116

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被引用次数: 6

摘要

Neutrophils play a pivotal role in the pathophysiology of multiple human inflammatory diseases. Novel pharmacological strategies which drive neutrophils to undergo programmed cell death (apoptosis) have been shown to facilitate the resolution of inflammation. Both the cyclin-dependent kinase inhibitor (CDKi) R-roscovitine and nitric oxide (NO) have been shown to enhance apoptosis of neutrophils and possess pro- ...