The Journal of Organic Chemistry

Novel and Convenient Routes to Functionalized Alkynyl Ketones from 1-(Benzotriazol-1-yl) propargyl Ethyl Ethers

AR Katritzky, H Lang

文献索引：Katritzky, Alan R.; Lang, Hengyuan Journal of Organic Chemistry, 1995 , vol. 60, # 23 p. 7612 - 7618

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被引用次数: 58

摘要

1-(Benzotriazol-1-yllpropargyl ethyl ethers, readily accessible from propargyl aldehyde diethyl acetals and benzotriazole, undergo smooth lithiation at the methine carbon and subsequent reactions with alkyl halides, aldehydes, ketones, imines, esters, trialkylsilyl chlorides, dialkyl carbonates, and isocyanates to yield the corresponding substituted ethers. Hydrolysis of these intermediates under acidic conditions affords a wide variety of alkynyl ...