3, 5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4 (1 H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity

…, S Gaur, AM Palmer, K Benwell, V Harvey…

文献索引：Bebbington, David; Monck, Nathaniel J. T.; Gaur, Suneel; Palmer, Alan M.; Benwell, Karen; Harvey, Victoria; Malcolm, Craig S.; Porter, Richard H. P. Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2779 - 2782

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被引用次数: 43

摘要

Introduction. For many years radical scavenging antioxidants have been successfully used to protect synthetic materials and food products from the degrading process of oxidation. 1 More recently a role as neuroprotective agents for the treatment of disorders known to involve oxidative stress (eg stroke, traumatic brain injury, Parkinson's disease, and Alzheimer's disease) has been proposed and supported by animal models. 2 The ...