Synthesis of halogen-substituted 1, 5-benzothiazepine derivatives and their vasodilating and hypotensive activities

…, T Hashiyama, H Otsuka, K Takahashi…

文献索引：Inoue, Hirozumi; Konda, Mikihiko; Hashiyama, Tomiki; Otsuka, Hisao; Takahashi, Kaoru; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 675 - 687

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被引用次数: 81

摘要

4 mL of dry acetonitrile were added, and the mixture was stirred overnight. After filtration to remove a small amount of insoluble solid, the mixture was concentrated to dryness under reduced pressure. The residual oil was redissolved in 4 mL of acetonitrile, and with ice cooling, 0.16 mL of methanol was added. The mixture ... . , Acknowledgment. We thank members of our Physical Chemistry Department for Providing spectral data, @Pe- cially Mr. Gin0 Sass0 who ...