Over the last eight years, we have developed bimetallic titanium(salen) complex 1 as a highly enantioselective and remarkably versatile catalyst for the asymmetric addition of various cyanide sources to aldehydes 1 and ketones. 2 Catalyst 1 will induce the asymmetric addition of trimethylsilyl cyanide, 3 potassium cyanide/an anhydride 4 and ethyl cyanoformate 4c and 5 to aldehydes, providing access to non-racemic cyanohydrin trimethylsilyl ethers, ...
