The Journal of Organic Chemistry

Lactone chemistry. Synthesis of. beta.-substituted,. gamma.-functionalized butan-and butenolides and succinaldehydic acids from glyoxylic acid

JJ Bourguignon, CG Wermuth

文献索引：Bourguignon, J. J.; Wermuth, C. G. Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 4889 - 4894

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被引用次数: 62

摘要

The Mannich-type aminoalkylation reaction of enolizable aldehydes with morpholine and glyoxylic acid instead of formaldehyde was investigated in basic and neutral media were obtained a, y-dimorpholinobutanolides 2 and a-morpholino-y-hydroxybutanolides 1, respectively. In acidic medium the spontaneous elimination of the a-morpholino group afforded the y-hydroxybutenolide 8. The reaction pathways were suggested from the ...